The Colts have been due for a big win and I think they may finally have the pieces clicking this week to make it happen, but it won't happen since Mariota and the Titans will actually have put in the time and preparation after their mini-bye (they lost to Steelers on Thursday Night Football a week and a half ago).
I'm not seeing the Titans favored by very much here, which is strange, so I'm picking them to win it, straight-up!