Icosahedron

Efficient synthesis and utilization of phenyl-substituted heteroaromatic carboxylic acids as aryl diketo acid isosteres in the design of novel HIV-1 integrase inhibitors

https://db.cngb.org/search/literature/18662877/

Three new types of aryl diketo acid (ADK) isosteres were designed by conversion of the biologically labile 1,3-diketo unit into heteroaromatic motif such as isoxazole, isothiazole, or 1H-pyrazole to improve the physicochemical property of ADK-based HIV-1 integrase (IN) inhibitors. The synthesis of the heteroaromatic carboxylic acids was established by employing phenyl beta-diketoester or benzaldehyde as the starting material and 1,3-dipolar cycloaddition as the key reaction. Of the compounds tested, the 3-benzyloxyphenyl-substituted isoxazole carboxylic acid displayed the best IN inhibitory and antiviral activities, with N-hydroxylamidation enhancing the in vitro and in vivo potency. These findings are important for further optimization of ADK-based IN inhibitors.

Methylated Polyphenol

https://en.m.wikipedia.org/wiki/Quercetin

https://en.m.wikipedia.org/wiki/Methylation

https://en.m.wikipedia.org/wiki/Mast_cell#Mast_cell_activation_disorders

https://en.m.wikipedia.org/wiki/Mast_cell_activation_syndrome

Lipid Nanoparticles
Mycoplasma Acholeplasma
Cell Membrane

Lipid composition of mycoplasmas analyses transbilayer distribution of lipids in mycoplasma and acholeplasma cell membranes.

Lipid Nanoparticles in the vaccine are Mycoplasma Laboratorium.

Obligate intracellular parasites cannot reproduce outside their host cell, meaning that the parasite's reproduction is entirely reliant on intracellular resources.

Obligate intracellular parasites of humans include:

Viruses: All

Bacteria:

Chlamydia
Rickettsia
Coxiella
Mycobacterium

Protozoa:

Apicomplexans
Plasmodium
Toxoplasma Gondii
Cryptosporidium Parvum
Trypanosomatids
Leishmania
Trypanosoma Cruzi

Fungi:

Pneumocystis Jirovecii

Exceptions:

Polypodium is a metazoan intracellular parasite, distinct from most if not all other intracellular parasites.

https://en.m.wikipedia.org/wiki/Intracellular_parasite#Obligate

https://en.m.wikipedia.org/wiki/Acholeplasma

https://en.m.wikipedia.org/wiki/Lipid_II

https://en.m.wikipedia.org/wiki/Chlamydia_(genus)

Lipid II is a precursor molecule in the synthesis of the cell wall of bacteria. It is a peptidoglycan, which is amphipathic and named for its bactoprenol hydrocarbon chain, which acts as a lipid anchor, embedding itself in the bacterial cell membrane.

Targeted Delivery of Adamantylated Peptidoglycan Immunomodulators in Lipid Nanocarriers.

https://www.sciencedirect.com/topics/chemistry/peptidoglycan

https://en.m.wikipedia.org/wiki/Ribosome

Lipid Nanoparticle Synthia

the mycoplasma nanoparticles use the same chemical as cells called Ribosome for manufacturing mRNA.

thats why they can classify mycoplasma as only lipid nanoparticles.

inside the lipid nanoparticles are Intracellular Parasite Obligate.

Ribosome
hosting the mRNA Intracellular Parasite Obligate.

Ufology & Virology have a lot in common, official story of Virus looks like a UFO, by not taking into account the identical symptoms & behavioral patterns of what is already known to exist in ancient history.

UFO Demonology
Virus Parasitology

for example ..

if Endosymbionts & Virus are both classified as Obligate Intracellular Parasites, does that mean they symbiont are not alive? like the definition of a virus?

are demons alive or dead? just like a virus, they appear to be undead.

Cnidaria
Polypodium
Myxozoa
Myxosporea

Recruitment of toxin-like proteins with ancestral venom function supports endoparasitic lifestyles of Myxozoa

https://peerj.com/articles/11208/

https://en.m.wikipedia.org/wiki/Polypodium_(animal)

https://en.m.wikipedia.org/wiki/Myxozoa

https://en.m.wikipedia.org/wiki/Myxosporea

this appears to be the origin root of Obligate Intracellular Endosymbiont.

meaning diseases in ticks, are the same species, meaning Alphaproteobacteria may be mislabeled as bacteria.

Myxozoa Polypodium is a species related to Hydra Vulgaris, and some the size of a virus.

immoral stem cell, species specific, intracellular, size of virus, manufacture venom.

its possible that virus are just bad dna programing, but they appear to have parasitic attributes, and similar medicine application.

why do viruses have receptors to sugar?

another similarly to parasites.

lectin binding & pathway
glucose glycosylation

if the virus is eating sugar, then that is a point to target using phenols, redox, chelation & electron binding.

ticks-survive-for-27-years-in-entomologists-lab

https://www.binghamton.edu/news/story/3485/ticks-survive-for-27-years-in-entomologists-lab

Myxozoan Parasite in Brain of Critically Endangered Frog

https://wwwnc.cdc.gov/eid/article/18/4/11-1606_article

Engineering of obligate intracellular bacteria: progress, challenges and paradigms

https://www.nature.com/articles/nrmicro.2017.59

Myxozoa
Myxovirus

https://www.britannica.com/science/myxovirus

Myxozoa live inside cells & produce spores that look like Myxovirus.

What came first, cells or viruses?

https://cosmosmagazine.com/science/biology/what-came-first-cells-or-viruses/?amp=1

https://en.m.wikipedia.org/wiki/Organic_redox_reaction

https://en.m.wikipedia.org/wiki/Amalgam_(chemistry)

https://en.m.wikipedia.org/wiki/Reducing_sugar

https://en.m.wikipedia.org/wiki/Alkalinizing_agent

https://en.m.wikipedia.org/wiki/Microsporidia

https://en.m.wikipedia.org/wiki/Hyperparasite

sea salt used for rexox failed, to much Sodum & not enough Alkaline minerals to neutralize the other acids, specially Nitrogen, specially Magnesium Potassium & Zinc.

fire ash (potash) has the correct ratio of Alkalinizing agents.

my previous experiments last year used wood ash instead of sea salt, my skin was becoming dry using sea salt, when previously using Potash it was so strong with Collagen, it was the Potassium.

Potassium is one of the only minerals that directly bonds to Phenyl, making Polyphenol capable of redox chelation into parasites.

im not looking for fancy drugs, only simple & effective treatment that will safely cure disease, bind parasites & reinforce critical biological functions, with ingredients from grandmother kitchen.

it just needs to be done correctly, without any guesswork.

Baking soda does not contain the healthy mix of minerals like magnesium to balance calcium, potassium to balance sodium and zinc to balance copper that are essential to maintain cell energy and function.

bicarbonate can precipitate leaching of magnesium and calcium, potassium and sodium, zinc and copper. These and other microminerals.

Intake of baking soda does not induce repair or stimulate alkaline cell renewal.

Appropriate intake of potassium has a protective effect against lung cancer, while high consumption of sodium is associated with an increased risk of lung cancer.

HeLa
Immortal Cell Line

Tubulin (HeLa)
HLA-DR (DR2)

Cell biologist George Otto Gey found that HeLa cells could be kept alive, and developed a cell line. Previously, cells cultured from other human cells would only survive for a few days. Cells from Lacks's tumor behaved differently.

Each sample quickly died in Dr. Gey’s lab. What Dr. Gey would soon discover was that Mrs. Lacks’ cells were unlike any of the others he had ever seen: where other cells would die, Mrs. Lacks' cells doubled every 20 to 24 hours.

To develop an in vitro model system for studying prion biology in cerebellar cells, we established and characterized an immortal cell line (CRBL) isolated from the cerebellum of mice lacking expression of a protein involved in cell cycle arrest. The characteristics of the cells include morphological heterogeneity, rapid proliferation.

Myxozoa are microscopic endoparasites that colonize invertebrates and vertebrates.

One of the most well-known experiments is the induced regression of a mature medusa of the immortal jellyfish Turritopsis spp. (Hydrozoa).

Chlorophyll
Organic Acids
Nitrogen Sulphur

Caramelize
Carbohydrate (Sugar)
Phenol (Carbon)

Alkaline
Potash (Ash)
Potassium Magnesium Zinc

Oil
Fatty Acid (Hydrogen)
Medium Chain Triglyceride

Chemical Elements

https://en.m.wikipedia.org/wiki/List_of_chemical_elements

0/1=2=3=4
0/1=2=3=5
0/1=2=3=6
0/1=2=3=7
0/1=2=3=8

Neutron (0)
Hydrogen (1)
Helium (2)
Lithium (3)
Beryllium (4)
Boron (5)
Carbon (6)
Nitrogen (7)
Oxygen (8)
Fluorine (9)
Neon (10)
Sodium (11)
Magnesium (12)
Aluminium (13)

this is a little window into holographic universe & chemistry.

Protein Folding depends upon the root algorithm.

Neutron may be a better representation of 0.

Proton & Hydrogen are the same element with two names, and polarity is unusual.

Proton is light & Nutron is the fuel.

meaning the fire makes soot, that makes physical matter, makes a shadow of the light.

Proton is Hydrogen

0/1 are oppsite and one unit.

0=Nutron

making Electron a reaction, not a particle or element.

Quarks represent Antimatter O & Trinity in both directions, Carbon is 6 & first physical material atom.

3 Quarks make a Proton, also called Hydrogen Element.

Mineral requirements for mitochondrial function: A connection to redox balance and cellular differentiation

https://www.sciencedirect.com/science/article/pii/S0891584922000752?via%3Dihub

Mannose and Mannose-6-Phosphate Receptor-targeted Drug Delivery Systems and their application in Cancer Therapy

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108418/

this article is the foundation of my recipe idea.

Carbon carbohydrate sugar mannose, can be cooked, reduced converted into a simple sugar, sugar alcohol, polyol & phenol, when combined with Nitrogen & Sulfur link into Polyphenol.

the goal is to make the minerals small & charged with electrons, thats about it, so they bind to any kind of parasite & clean mitochondria.

Impacts of selected dietary polyphenols on caramelization in model systems

https://www.sciencedirect.com/science/article/abs/pii/S0308814613008303

Carbon Benzene Phenol Polyphenol Carbohydrate Sugar Caramel

Soluble Fiber
Water Soluble
Activated Charcoal

that is likely synthesized via caramelization of sugars.

both Hydrogen & Carbon have unusual electrical properties, they can do both directions.

ion bind to oppsite polarity of all parasites, virus included, it binds them up as well, regardless of the identification of a virus, the cure is the same.

all medicine is ion electron binding to oppsite polarity.

trying to bypass trace minerals as necessary parts of the medicine, by using only the most safe mineral ionic elements, such as Calcium & Magnesium.

trying to bind Polyphenol to them instead of Zinc of Silver, for the same effect.

a tea spoon of Calcium or Magnesium will settle an upset stomach, but a teaspoon of Zinc will be death.

Phenol is used to stain mycoplasma for identification.

Polyphenol binds Ionic Minerals into the parasite & binds them up.

DMSO
Organosulfur
Thioctic Acid
Lipoic Acid
Caprylic Acid
Carboxylic Acid
Carbohydrate
Triglyceride
Milk